The Twelve is a group of Rygor's guardians. The party will fight them all throughout the storyline in the order of their appearance.
- The Magus Sisters: Cindy, Sandy, and Mindy
- The Twins: Lilith and Lillisete
- The names Argento, Rosso, Azul, Nero, Weiss, and Shelke are the names of members of the Tsviets from Dirge of Cerberus -Final Fantasy VII-, "Sable" is Nero's title, "Roeas" is an antagonist in The Last Remnant, and Lilith and Lilisete's names are taken from previous characters from the series. The Magus Sisters are a recurring enemy throughout the series.
- No two members are fought within the same chapter, with the exception of The Magus Sisters and Lilith and Lilisete.